基质金属蛋白酶在牙本质龋中的作用

The role of matrix metalloproteinases in dental caries

基质金属蛋白酶(MMPs)是一类蛋白水解酶,在体内可水解细胞外基质成分。在牙本质龋发生的过程中,致龋菌释放的酸使pH值下降,来自于唾液和牙本质的MMPs被激活,当唾液缓冲系统使pH值恢复中性后,MMPs可水解脱矿的牙本质。基质金属蛋白酶抑制剂如MMPs组织特异性抑制剂及从天然来源的物质中提取出的某些成分可有效抑制MMPs活性。本文就MMPs生物学特性、在牙本质龋中的作用以及其抑制剂的研究进展作一综述。

Matrix metalloproteinases(MMPs) are a family of proteolytic enzyme which are capable of hydrolyzing components of the extracellular matrix(ECM). MMPs originated from saliva and from dentin may be activated by an acidic pH brought about by lactate release from cariogenic bacteria in the progression of dental caries. They are able to digest demineralized dentin matrix after pH neutralization by salivary buffers. Tissue inhibitor of met- alloproteinases(TIMPs) are the physiological inhibitor of the MMPs. Some ...