替米沙坦对慢性心衰患者细胞因子和心功能的影响

The effects of telmisartan on serum cytokine levels and left ventricular function in patients with chronic heart failure

目的本研究旨在探讨替米沙坦对慢性心力衰竭患者细胞因子和左心室功能的影响。方法选择慢性心力衰竭患者80例,随机分为替米沙坦组(40例)和对照组(40例),治疗组在常规治疗基础上口服替米沙坦80mg/d,疗程为1年。检测两组患者治疗前后血清白细胞介素-1(Interleukin-1,IL-1)、白细胞介素-6(Interleukin-6,IL-6)和肿瘤坏死因子-α(TNF-α)等细胞因子水平和左心室功能指标。结果两组患者治疗后IL-1、IL-6和TNF-α水平均较治疗前降低(P<0.05,P<0.05和P<0.05),但替米沙坦组改变较对照组更为明显(P<0.05,P<0.05和P<0.05)。两组患者左心室功能均明显改善(P<0.05),但替米沙坦组改变较对照组更为明显(P<0.05)。结论替米沙坦能有效降低慢性心力衰竭患者细胞因子水平,改善左心室功能,是慢性心力衰竭治疗的理想药物。

Objective To investigate the effects of telmisartan on the serum cytokine levels and left ventricular function in patients with chronic heart failure. Methods Eighty cases of patients with chronic heart failure were chosen and randomly divided into two groups, which included telmisartan group (40 cases) and control group (40 cases). The patients in telmisartan group were administrated telmisartan 80mg/d for one year on the basis of traditional treatment. Before and after the treatment, the serum levels of c...