阻塞性睡眠呼吸暂停低通气综合征患者血栓前相关因素和脂蛋白(a)的研究

A study on prethrombosis relative factors and lipoproteina in patients with obstructive sleep apnea-hypopnea syndrome

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血栓前相关因素和脂蛋白(a)的变化,探讨其与OSAHS及心脑血管疾病的关系。方法测定36例OSAHS患者和30例健康对照组的全血高切粘度,低切粘度及血浆粘度,凝血酶原片段1+2(F1+2)、血浆抗凝血酶Ⅲ、P-选择素、D-二聚体及脂蛋白(a),并比较其差异。结果OSAHS组与健康对照组比较,除血浆抗凝血酶Ⅲ活性降低(P<0.05),余均升高(P<0.05)。相关分析发现全血高切粘度、F1+2、P-选择素、D-二聚体、血浆抗凝血酶Ⅲ活性、脂蛋白(a)与呼吸紊乱指数、最低血氧饱和度、最长呼吸暂停时间及血氧饱和度<90%时间占总睡眠时间百分比(STT90)均相关(P<0.05),全血低切粘度及血浆粘度与呼吸紊乱指数及STT90相关(P<0.05)。结论OSAHS患者存在血流动力学异常,凝血、抗凝、纤溶状态、血小板活性变化及脂蛋(a)增高可能是OSAHS患者易合并心脑血管疾患的重要原因。

Objective To investigate the changes of relative factors and lipoproteina in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) with thrombosis and seek their relationship with cardio cereberal antipathy disease and OSAHS. Methods 36 patiencts with OSAHS and 30 healthy individuals were selected and the following factors were measured and compared: whole blood high shear viscosity, low shear viscosity and plasma viscosity,prothrombin fragment1+2(F1+2), plasma ant thrombin Ⅲ, P-selection element,...