针药联合对局灶性脑缺血大鼠神经细胞功能的影响

Effect of Acupuncture Combined with Herb Decoction on Nerve Cell of Focal Brain Ischemia Rats

目的探讨针药联合治疗脑梗死的疗效与机理。方法以热凝法阻断大鼠一侧大脑中动脉(McAo)造成局灶性脑缺血为实验模型。将动物随机分为4组:模型组、中药组、针刺组、针药结合组。观测各组缺血区脑组织c-fos蛋白表达48h之内的动态变化。结果3个治疗组均能明显增强c-fos蛋白的表达,其中针药结合组明显优于其它组。结论针药联合能明显提高缺血区c-fos蛋白的含量,改善神经细胞的应激能力。比单独应用中药或针刺更有效。

Objective To study the mechanism of acupuncture combined with herb decoction for brain occlusion. Methods one-side middle cerebral artery occlusion (McAo) rat by ehermoregulation was used as focal cerebral ischemia experimental animal. All animals were divided into four groups as model group, acupuncture group, herb decoction group, acupuncture combined with herb decoction group. And the dynamic changes of c-fos protein in ischemia region of brain tissue after treatment were observed. Results All of acupunc...