摘要
目的:探讨及研究建立急性吗啡成瘾猫模型的方法。方法:将12只猫随机分成实验组和对照组,实验组9只,对照组3只。实验组按逐日递增原则,分别于每日8点、12点、16点行背部皮下注射盐酸吗啡。第一天吗啡单次用量5mg·kg-1,之后分别为10mg·kg-1、15mg·kg-1、20mg·kg-1、25mg·kg-1。连续5天给药。第6天实验组以0.5mg·kg-1纳洛酮诱发戒断症状。比较实验组和对照组猫的戒断症状。结果:实验组纳络酮诱发戒断症状与对照组的比较,经统计学处理显示组间差异很显著。结论:急性吗啡成瘾猫模型的建立是切实可行的。
Objective:To establish the model of acute mouphinomania in cats.Methods:Twelve male cats were random divided into experiment groupand control group,experiment group is nine cats control gruop is three cats.Experiment group cats inject morphine with 5mg.kg-1,10mg.kg-1、15mg.kg-1、20mg.kg-1、25mg.kg-1 experiment dosage at eight,twelve and sixteen o clock and successive five days.At the sixth day,experiment group cats inject naloxone to compare the difference of whthdrawal symptom in ecperiment group and control ...
出处
《脑与神经疾病杂志》
2008年第6期711-712,共2页
Journal of Brain and Nervous Diseases
基金
河北省科技攻关计划项目(07276101D-133)
关键词
吗啡急性成瘾
猫模型
戒断
quickly for morphinomania cat model withdrawal
