莽草酸的应用及其微生物代谢合成

Application of Shikimate and its Synthesis by Microbial Metabolism

莽草酸是一种高价值的药用原初产物,其衍生物在抗炎、抗肿瘤、抗心血管疾病、抗禽流感等方面有重要的作用。通过综述莽草酸的理化性质、药理特性及生产方法,并结合国内外的最新研究进展,重点探讨微生物代谢合成在提高莽草酸生产效率中的应用。

Shikimic acid is a valuable initial material used in pharmaceutics.Its derivates have been found to be involved in anti-inflammatory,anti-tumor,anti-cardiovascular diseases and against the avian influenza.The physicochemical property,pharmacologic characters and the production methods of the shikimate were reviewed in this paper.On the basis of recent progress at home and abroad,this paper focused on shikimate metabocic synthesis by microbe and methods for improving the production efficiency.