血清C反应蛋白和D-二聚体联合检测在溃疡性结肠炎病情活动性判断中的价值

Value of Combined Examination of C-reactive Protein and D-dimer in Ulcerative Colitis

目的通过检测溃疡性结肠炎(UC)患者的血清C反应蛋白(CRP)及D-二聚体水平,探讨二者在UC患者病情活动及严重程度判断中的应用价值。方法分别采用胶乳增强免疫比浊法与免疫扩散比浊法检测64例活动期UC患者、45例缓解期UC患者及40例健康对照者血清CRP及D-二聚体水平,并对活动期患者行肠镜及病理组织学检查,评价病情程度。结果(1)活动期UC组患者血清CRP及D-二聚体水平与缓解期UC组及对照组比较,差异均有统计学意义(P<0.01);缓解期UC组CRP水平与对照组比较,差异有统计学意义(P<0.05),而D-二聚体水平与对照组比较,差异无统计学意义(P>0.05)。(2)重型UC患者血清CPR及D-二聚体水平与轻、中型患者比较,差异有统计学意义(P<0.05)。结论血清CRP及D-二聚体水平可作为评价UC患者病情活动性及严重程度的良好指标。

Objective To investigate the value of serum C-reactive protein (CRP) and D-dimer in determination of disease activity and its severity of the patients with ulcerative colitis (UC).Methods The contents of serum CRP and D-dimer of 64 UC sufferers at active stage,45 at remission stage,and 40 normal controls were conducted by latex-enhanced immunosuppressive turbidimetry and immunodiffusive turbidimetry respectively.And the intestines of the sufferers at active stage were examined by enteroscopy and pathologica...