不同镇静深度下异丙酚与咪达唑仑顺行性遗忘效应的比较

Anterograde Amnesia of Propofol and Midazolam in Different Sedation Depth

目的比较不同镇静深度下异丙酚与咪达唑仑的顺行性遗忘效应。方法选取重症监护病房(ICU)患者31例,随机分为两组,异丙酚组17例,静脉泵入异丙酚0.5～1.5mg·kg-1·h-1;咪达唑仑组14例,静脉泵入咪达唑仑0.04～0.15mg·kg-1·h-1。分别在患者脑电双频谱指数(BIS)值>90、85～75、74～65、<65时观看不同的纸牌,在患者恢复清醒(BIS值>90)后令其回忆所看到的纸牌,计算回忆纸牌错误率。结果两组患者在各个BIS值区间回忆纸牌错误率间差异均无统计学意义(P>0.05)。异丙酚组患者在BIS值74～65、BIS<65区间的回忆错误率与清醒时(BIS值>90)比较,差异有统计学意义(P值分别为0.008、0.005);咪达唑仑组患者在BIS值85～75、74～65、<65区间的回忆错误率与清醒时(BIS值>90)比较,差异有统计学意义(P值分别为0.038、0.004、0.000)。结论异丙酚与咪达唑仑一样具有顺行性遗忘效应,但需要在较深的镇静深度才可实现;咪达唑仑在较浅的镇静深度即具有顺行性遗忘效应。

Objective To evaluate anterograde amnesia of propofol and midazolam by bispectral index (BIS) in different sedation depth.Methods 31 screened post-operation-patients without craniocerebral operation were investigated.All of the patients were randomly divided into two groups,propofol(0.5-1.5mg/kg/hr) group (n=17),midazolam(0.04-0.1.5mg/kg/hr)group (n=14).The sedative patients had been ordered to see the number cards in the sequence of the BIS>90,85-75,74-65,<65.The patients remembered the number cards ...