复发性外阴阴道假丝酵母菌病致病菌的耐药性监测和ERG11基因研究进展

Progress in Research of Drug-resistance of Recurrent Vuvovaginal Candidiasis Pathogenic Bacteria and ERG11 Gene

复发性外阴阴道假丝酵母菌病(recurrent vulvovaginal candidiasis,RVVC)指1年中发生4次或以上的外阴阴道念珠菌病,引起RVVC的病原菌主要是假丝酵母菌属中的白假丝酵母菌。唑类抗真菌药物在临床上应用广泛,其耐药现象占酵母样真菌耐药首位。14α去甲基酶(14-α-Demethylase,14-DM)为白假丝酵母菌与唑类抗真菌药物作用的关键靶酶,羊毛固醇14α去甲基化酶(Lanosterol 14-α-Demethylase Gene,ERG11)基因是编码14-DM的基因,该基因突变和基因过度表达在介导白假丝酵母菌对唑类药物耐药中发挥了重要作用。本文就ERG11基因突变和基因过度表达在RVVC患者白假丝酵母菌对唑类药物耐药做一综述。

Recurrent vulvovaginal candidiasis(RVVC)refers to a kind of vulvovaginal candidiasis which occurs 4 times or more in 1 year,caused mainly by candida albicans(CA),a kind of candida mycoderma.The resistance to triazole antifungal drugs widely used in clinical practice takes the first place in yeast-like fungus.14-α-Demethylase(14-DM) is a key target enzyme in the action of CA and triazole antifungal drugs,and lanosterol 14-α-demethylase(ERG11)gene is the coding of 14-DM,whose mutations and over-expression pla...