痰铜绿假单胞菌2002—2005年分离率及耐药性分析

Analysis of Isolating Rate and Drug Resistance of Pseudomonas Aeruginosa in Sputum from Year 2002 to 2005

目的了解我院痰铜绿假单胞菌(PAE)的分离率及耐药性的变迁,为临床合理选择抗菌药物提供依据。方法回顾性分析2002年1月—2005年7月痰中PAE分离率及其对16种抗菌药物的耐药率。结果(1)2002—2005年4年间PAE分离率差异有统计学意义(P<0.01);(2)2002年痰中PAE对妥布霉素、亚胺培南、哌拉西林、环丙沙星和左旋氧氟沙星的敏感率与2005年比较差异有统计学意义(P<0.05);(3)2004年入住ICU患者的PAE对庆大霉素、阿米卡星、妥布霉素、左旋氧氟沙星敏感率与非入住ICU的患者比较差异有统计学意义(P<0.05),但2005年ICU的患者PAE对上述药物的敏感率与非ICU比较差异无统计学意义(P>0.05)。结论PAE的分离率和耐药率均较高,医务人员需监测PAE耐药特点及变迁,科学合理地使用抗菌药物。

Objective To investigate the changes of isolating rates and drug resistance of Pseudomonas aeruginosa(PAE) in sputum specimens collected by our hospital to supply guidance of rational clinical use of antimicrobials.Methods A statistic analysis on isolating rate and drug resistance of PAE strains collected from sputum was conducted retrospectively.Results PAE isolating rates of years from 2002 to 20005 were 9.7%,7.6%,12.9% and 18.9%,respectively.The PAE resistance to ampicillin,ampicillin/sulbactam,cefozolin...