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同源异盒基因BP1在肺癌和肺结核鉴别诊断的研究 被引量：1

Study on the diagnostic value of homeobox BP1 mRNA expression for pulmonary cancer from pulmonary tuberculosis
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摘要 目的:研究BP1基因mRNA对肺癌与肺结核鉴别诊断的意义,为肺癌与肺结核临床鉴别诊断提供实验依据。方法:采用实时荧光定量RT-PCR技术,在Rotor-Gene3000型检测仪上定量检测肺癌的癌组织、肺结核组织中BP1基因的表达程度及意义。结果:实时荧光定量RT-PCR检出BP1基因在46例肺癌组织中有36例呈高表达(78.3%),在52例肺结核组织中仅4例有表达(7.7%),肺癌组织和肺结核组织中BP1基因的表达率之间存在显著性差异(P<0.01);在21例高分化标本中检出13例呈中高表达,在25例低分化标本中检出22例呈中高表达,两者之间存在显著性差异(P<0.01);BP1基因表达程度在20例Ⅰ-Ⅱ期肺癌标本检出12例呈中高表达,在26例Ⅲ-Ⅳ期标本中检出15例呈中高表达,两者之间无显著性差异((P>0.05);BP124例鳞癌中21例呈高表达,22例腺癌中19例高表达,两者无显著性差异(P>0.05)。结论:BP1基因的检测可以作为肺癌诊断以及与肺结核鉴别诊断的指标;BP1基因的表达可能与肺癌分化程度有关,与病理类型和TNM分期无关。 Objective:To explore the expression of BP1 gene in pulmonary cancer tissue and pulmonary tuberculosis tissue for differentiation of pulmonary cancer from pulmonary tuberculosis.Methods: The expression of BP1 gene was detected in patients with pulmonary cancer(n=46),pulmonary tuberculosis(n=52) with reverse transcription-polymerase chain reaction(RT-PCR).Results: The expression of BP1 gene in pulmonary cancer tissue was(78.3%),significantly higher than that in pulmonary tuberculosis tissue(7.7%).Twenty-eight...
作者 线胤生 弓显凤 阎春霞
机构地区 西安交通大学医学院第一附属医院肿瘤外科 西安市结核病医院 西安交通大学环境与疾病相关基因教育部重点实验室
出处 《现代肿瘤医学》 CAS 2008年第11期1922-1924,共3页 Journal of Modern Oncology
基金 陕西省国际合作重点项目(2004KW-22)
关键词 BP1基因 肺癌 肺结核 RT-PCR BP1 gene pulmonary cancer pulmonary tuberculosis RT-PCR
分类号 R734.2 [医药卫生—肿瘤]
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参考文献12

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二级参考文献16

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现代肿瘤医学
2008年 第11期

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