2型糖尿病合并非酒精性脂肪肝与胰岛素抵抗的关系(附62例分析)

Relationship between nonalcoholic fatty liver with type 2 diabetes and insulin resistance:Analisis of 62 cases

目的探讨2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFL)与胰岛素抵抗、高敏C反应蛋白(hs-CRP)的关系。方法检测T2DM合并NAFL组(DNAFL组,62例)和2型糖尿病非脂肪肝组(DNFL组,30例)患者血脂、空腹血糖(FBG)、空腹胰岛素(FINS)、尿酸(UA)、hs-CRP等指标。结果DNAFL组较DNFL组的体质指数(BMI)、腰臀比(WHR)、FBG、糖基化血红蛋白(HbA1c)、FINS、HOMA-胰岛素抵抗指数(HOMA-IR)、TG、TC、UA和hs-CRP均升高(P<0.05),胰岛素敏感指数降低(P<0.05)。Logistic回归分析显示,BMI、UA和HOMA-IR是NAFL的主要危险因素,优势比(OR)为2.38、1.01、1.95,95%可信区间分别为1.33～4.27,1.01～1.02,1.14～3.33(均P<0.05)。结论DNAFL患者存在胰岛素抵抗,NAFL可能是代谢综合征的组分。

Objective To investigate the relationship of nonalcoholic fatty liver(NAFL)with type 2 diabetes with insulin resistance and level of high sensitive C-reactive protein(hs-CRP).Methods Serum lipids,fasting blood glucose(FBG),fasting insulin(FINS),urine acid(UA)and hs-CRP were measured in patients of 62 nonalcoholic fatty liver with type 2 diabetes(DNAFL)and 30 nonfatty liver with type 2 diabetes(DNFL).Results The results showed that body mass index(BMI),waist-hip ratio(WHR),FBG,HbA1c,FINS,HOMA-IR,triglyceride...