摘要
目的比较急性心肌梗死(AMI)后6h内和6~12h缺血后适应对急诊经皮冠状动脉介入治疗(PCI)疗效的影响。方法将160例首次AMI患者随机分为<6h缺血后适应组(甲A组)、<6h对照组(甲B组)、6~12h缺血后适应组(乙A组)、6~12h对照组(乙B组)。对照组梗死相关动脉(IRA)再通后5min内不施加干预;缺血后适应组IRA再通后1min内应用低气压充盈和回撤球囊,每次循环时间为60s,共循环4次。结果甲A组心肌梗死溶栓试验(TIMI)血流≤2级、心肌灌注(Blush)分级<2级的构成比分别为7.5%、12.5%,均显著小于乙A组的30.0%、32.5%(P值均<0.05);两组术后TIMI血流及Blush分级的差异均有统计学意义(P值分别<0.05、0.01)。甲A组的AMI后各时间点磷酸肌酸激酶(CK)平均值连线后曲线下面积为57998,显著低于乙A组的79868(P<0.05)。甲A组随访期间的左心室舒张末期容积(LVEDV)、左心室舒张末期容积(LVESV)、室壁运动积分指数(WMSI)均较住院期间显著降低(P值均<0.05),而左心室射血分数(LVEF)显著增加(P<0.05)。随访期间,乙...
Objective To compare the effect of ischemic postconditioning on the efficiency of primary coronary intervention between 6 h and 6-12 h after the onset of acute myocardial infarction (AMI). Methods A total of 160 patients with primary AMI were randomly divided into the following groups: ischemic postconditioning within 6 h of AMI onset (A1), control within 6 h of AMI onset (B1), ischemic postconditioning during 6-12 h of AMI onset (A2), and control during 6-12 h of AMI onset(B2). In the 2 control groups pati...
出处
《上海医学》
CAS
CSCD
北大核心
2008年第10期694-699,共6页
Shanghai Medical Journal
基金
上海市科委登山计划科研项目(064119507)
关键词
心肌梗死
介入治疗
缺血后适应
Myocardial infarction
Coronary intervention
Ischemic postconditioning
