摘要
目的:对立血康软胶囊的提取工艺进行优化。方法:用乙醇作溶剂提取处方中2种药材的活性成分,按正交表L9(34)安排试验,以大黄素和大黄酚的总含量和浸膏收率为指标,对含量和浸膏收率以不同的权重系数加权评分,考察影响醇提取效率4个因素的主次。结果:醇溶性成分提取的最佳工艺为:70%乙醇回流提取3次,每次2 h,溶剂用量为8倍量。结论:本法能最大限度地提取处方中各种药材的有效成分,可为立血康软胶囊的工业化生产提供理论依据。
Objective:To optimize the extraction procedure of Lixuekang Soft Capsule.Method:The procedure was configired by a sampling of orthogonal design with different ethanol extraction solvent uses.The yield of extracts and the total contents of emodin and chrysophanol were used as assessment index and based on different weighted coefficient for evaluation of the extraction efficiency of ethanol.Result:The optimal procedure was using the circulation reflux for 3 times with 8 times 70% ethanol,2 hours each time.Con...
出处
《中国实验方剂学杂志》
CAS
2008年第10期20-22,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
黑龙江省教育厅资助课题(11521263)
关键词
立血康软胶囊
提取工艺
权重系数
大黄素
大黄酚
Lixuekang Soft Capsule
extraction procedure
weighted coefficient
emodin
chrysophanol
