摘要
目的:研究艾迪注射液抑制肿瘤生长的作用机理。方法:采用裸鼠人肺鳞癌移植瘤模型,造模10 d后,随机分为3组:对照组每日ip生理盐水0.2 mL,共20 d。艾迪组按12g.kg-1每日ip艾迪注射液0.2 mL(含生药1.2 g.mL-1),共20 d。化疗组按照1 mg.kg-1给小鼠ip 0.2 mL顺铂(DDP),共7 d。给药结束后处死动物,称瘤重;用免疫组化染色检测肿瘤血管密度和VEGF蛋白表达。结果:艾迪注射液和DDP的抑瘤率分别为45.6%和78.3%,艾迪注射液组血管密度降低,肿瘤组织VEGF蛋白表达减少,DDP组血管密度也降低,但肿瘤组织VEGF蛋白表达增加。结论:艾迪注射液可抑制肿瘤组织VEGF蛋白表达,降低肿瘤血管密度。
Objective:To explore the mechanism of the anti-tumor effect of Aidi Injection.Methods:Human lung squamous cell carcinoma xenografts were transplanted into 30 nude mice.Mice were randomLy divided into 3 groups:The Aidi Injection group received Aidi Injection(12 g·kg^(-1),0.2 mL,peritoneal injection) every day for 20 days,the chemotherapy group received DDP(1 mg·kg^(-1),0.2 mL peritoneal injection) every day for 7 days,and the control group received normal sodium(0.2 mL peritoneal injection) every day for 20 ...
出处
《中国实验方剂学杂志》
CAS
2008年第11期55-57,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
肺癌
艾迪注射液
抗血管生成
lung cancer
Aidi injection
anti-angiogenesis effect
