贝尼地平对原发性高血压患者血清hs-CRP和MCP-1的影响

Effect of Benidipine on high sensitive C-reactive protein and monocyte chemoattractant protein-1 in patients with primary hypertension

目的观察贝尼地平对原发性高血压患者血清超敏C-反应蛋白(hs-CRP)和单核细胞趋化因子-1(MCP-1)的影响。方法选择60例轻、中度原发性高血压患者,随机分为两组各30例,分别用贝尼地平和双氢克尿噻治疗3个月,每组治疗前后均检测血清hs-CRP和MCP-1水平;比较两组降压程度和对血清hs-CRP和MCP-1水平有无影响。结果治疗后两组血压水平下降明显,有统计学意义,贝尼地平组血清MCP-1和hs-CRP水平降低(P<0.01),双氢克尿噻组MCP-1和hs-CRP水平无明显改变。结论贝尼地平能减轻轻、中度高血压患者机体的炎症反应且这种作用不依赖于其降压效果。

Objective To investigate the effect of Benidipine on the serum level of high sensitive C-reactive protein(hs-CRP) and monocyte chemoattractant protein-1 in patients with primary hypertension.Methods60 patients with primary hypertension were recruited and divide into two groups randomly.After three months of Benidipine/Hydrochlorothiazide treatment, the venous blood was collected from all subjects to investigate hs-CRP and MCP-1.The effects of treatment of Benidipine/Hydrochlorothiazide on the serum levels o...