摘要
目的探讨辛伐他汀对急性肺血栓栓塞兔血清BNP的影响。方法选用30只新西兰健康白兔,随机分为对照组、模型组、辛伐他汀治疗组。采用兔自体血栓回输法建立急性肺栓塞模型。采用酶联免疫吸附法检测血清BNP的变化。结果栓塞后3h,模型组、治疗组BNP开始升高,分别达到(169.92±42.26)pg/mL、(162.50±35.75)pg/mL,与同期对照组(122.84±22.45)pg/mL比较差异有显著性(P<0.05);观察期间BNP浓度继续升高,栓塞后12h模型组、治疗组分别达到高峰,此后有逐渐下降趋势。结论急性肺血栓栓塞后,BNP浓度升高;辛伐他汀可降低肺栓塞后BNP水平;BNP可以作为肺栓塞的疗效及预后观察指标之一。
ObjectiveTo explore the change of serum B-type natriuretic peptide and effect of Simvastatin on acute pulmonary thromboembolism(APTE) rabbit model. MethodAPTE models were established by injecting autologous blood clots into femoral vein. 30 healthy zelanian rabbits were selected and divided into the control group(n =10) ,model group(n =10) ,Simvastatin therapy group(n =10) randomly. The changes of serum TNF-α,IL-1β and BNP(B-type Natriuretic Peptide) were tested with an enzyme-linked immunosorbent assay(ELI...
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第23期3460-3463,共4页
China Journal of Modern Medicine
关键词
肺血栓栓塞
动物模型
BNP
辛伐他汀
细胞因子
pulmonary thromboembolism
animal model
cytokines
Simvastatin
B-type natriuretic peptide
