甲状腺相关眼病的临床研究

Clinical research of thyroid associated ophthalmopathy

目的探讨甲状腺相关眼病(TAO)的临床特点及影响因素。方法203例TAO患者分为浸润性突眼组和单纯性突眼组,检测两组患者甲状腺激素和甲状腺自身抗体,比较年龄、性别、病程和不同方法治疗甲亢对TAO的影响。结果浸润性突眼组FT3、FT4明显高于单纯性突眼组(P<0.05),TSH低于单纯性突眼组(P<0.01)。浸润性突眼组促甲状腺素受体抗体(TRAb)滴度和阳性率明显高于单纯性突眼组(均P<0.05)。131I治疗甲亢后发生TAO者较抗甲状腺药物和手术治疗后多见(均P<0.01)。浸润性突眼组采用131I治疗甲亢明显多于单纯性突眼组(P<0.05)。两组甲状腺球蛋白抗体、甲状腺微粒体抗体差异无显著性。两组年龄、性别和病程差异亦无显著性。结论严重的甲状腺毒症、高TRAb滴度、131I放射治疗史可能是导致TAO恶化的因素。

ObjectiveTo study the clinical feature and the contributing factors of thyroid associated ophthalmopathy(TAO) . MethodsTwo hundred and three TAO cases were divided into infiltrative exophthalmos group and simple exophthalmos group. Thyroid hormone was measured by chemiluminescence. Thyroid antibody was measured by radioimmunity. Age,sex,course and methods of treating hyperthyroidism were compared in two groups. Results Sera FT3,FT4 in infiltrative exophthalmos group were significantly higher than in simple ...