摘要
目的:探讨p53蛋白表达与胃癌生物学行为的关系。方法:采用免疫组织化学法,检测p53蛋白在60例胃癌中的表达情况。结果:60例胃癌中p53阳性率为53.3%,p53蛋白表达与性别、年龄无关,与胃癌分期有关(P<0.05),p53表达阳性率随着胃癌分期的增加而升高。p53表达与胃癌分化程度有关(P<0.05),与淋巴结转移的数目也有一定关系(P>0.05)。结论:p53蛋白的表达与胃癌的分化程度、肿瘤组织的浸润程度、淋巴结数目的转移密切相关,它可作为评估胃癌预后的参考指标。
Objective To study the relationship between the expression of p53 proteins biologic behaviors of human gastric carcinoma.Methods Immunohistochemistry staining for p53 was performed on archival material from 60 gastric cancer.Results Results showed that positive p53 staining was 53.3% tumors examined.There is a highly significant correlation between p53 and tumor stage in gastric carcinoma(P<0.05).The proportion of p53 positively reacting gastric tumors inceases as the stage progresses.There was significa...
出处
《实用医技杂志》
2008年第27期3673-3674,共2页
Journal of Practical Medical Techniques
关键词
胃肿瘤
P53蛋白
生物学行为
Gastric carcinoma
p53 gene protein
Biological behavior
