多层螺旋CT灌注技术在肾脏肿瘤的应用研究

Study on the Technique of Multi-slice Spiral CT Perfusion in the Application of Kidney Tumor

目的:探讨多层螺旋CT体部肿瘤灌注技术在肾脏肿瘤中的诊断价值。方法:采用Siemens Somatom Sensation 40型多层螺旋CT的电影模式(1s/周),0.6mm层厚,40层,120kV,60mA,采用高压注射器注射非离子型对比剂50ml(300mgI/ml),流率4.0ml/s,延迟8s,数据采集55s,在siemens-mmwp Perfusion 2软件包分别测量16例肾癌、15例良性病变的血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面通透性(PS)的平均值,并进行统计分析。结果:多层螺旋CT比较容易获得灌注图像,可以清晰直观的显示出肿瘤大小和轮廓,并可定量检测肿瘤内部的组织灌注状态。肾癌组的BF、BV、MTT、PS的平均值分别为(250.81±21.88)ml/(100g·min)、(19.01±4.10)ml/100g、(9.87±3.90)s、(15.27±8.02)ml/(100g·min);良性病变组的BF、BV、MTT和PS的平均值分别为(70.82±6.91)ml/(100g·min)、(8.19±2.40)ml/100g、(10.11±1.67)s、(3.18±2.55)ml/(100g·min)。两组间比较,BF、BV、PS值差异具有统计学意义(P<0.05),MTT值则差异无统计学意义(P>0.05)。结论:肾脏良、恶性病变的BF、BV、PS值差异有统计学意义,MSCT灌注成像方法对其判断有一定诊断价值。

Objective To investigate the technique of Multi-slice Spiral CT perfusion with body tumor software package and evaluate the diagnosis value of its application of kidney tumor.Methods The multi-slice dynamic CT perfusion series was performed for thyroid perfusion with cine mode (1 s per rotation) on a multi-slice CT scanner (Siemens Somatom Sensation 40),40×0.6 mm collination,120 kV,60 mA Contrast injection was done by using 50 ml nonionic contrast agent (300 mgI/ml),at a flow rate of 4 ml/s with a power inj...