两种剂量辛伐他汀治疗高脂血症的疗效及安全性的临床观察

The Efficacy and Safety of Two Dosages of Simvastatin in Patients with Hyperlipidemia

目的:探讨辛伐他汀治疗高脂血症患者的疗效及安全性。方法:76例高脂血症患者,随机分为辛伐他汀20mg组(n=38)和40mg组(n=38),于晚睡前口服,治疗8周,监测血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、血清C反应蛋白(CRP)、肝肾功能、肌酸磷酸激酶,同时观察患者有无消化道症状、肌痛等不良反应。结果:两组血清TC、LDL-C、CRP浓度于治疗后均降低,与入院时比较均有统计学意义(P<0.01),两组间治疗后比较也有统计学意义(P<0.01)。结论:辛伐他汀对高脂血症患者的调脂有肯定的疗效,同时辛伐他汀强化降脂可有效调降血脂,且有良好的安全性及耐受性,无明显肝肾功能损害、肌溶解等不良反应。

Objective To investigate the efficacy and safety of simvastatin in patients with hyperlipidemia. Methods 76 patients with hyperlipidemia were randomized to the simvastatin 20 mg group(n=38)or simvastatin 40 mg group (n=38). All the patients took the drug orally before sleep for eight weeks. Serum TC, LDL-C, CRP, CK, liver function and renal function were measured before and after the treatment. The side effects such as myalgia and gastrointestinal symptom were also monitored. Results After treatment, serum ...