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胃癌血清IL-10和IL-12与肿瘤分期及血管生成的关系研究 被引量：3

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摘要 目的:探讨血清中IL-10、IL-12与胃癌病理分期及肿瘤血管形成的关系。方法:选取我院病理证实的36例胃癌患者做实验组,健康体检的28例做对照组,所有研究对象检测血清IL-10、IL-12含量,胃癌患者组织标本免疫组化表达血管内皮生长因子(VEGF)的含量并收集患者病理与临床指标。结果:胃癌患者血清IL-10含量比对照组血清中含量明显增加,胃癌分期较晚、有淋巴结转移、组织分化差的患者血清中IL-10含量比胃癌无淋巴结转移、分期与组织分化较好的患者含量高,而胃癌患者血清IL-12与之相反,且胃癌患者血清IL-10、IL-12的含量与胃癌组织中VEGF免疫组化表达相关。结论:胃癌患者血清IL-10、IL-12含量与胃癌淋巴转移、肿瘤分期、组织分化等病理参数相关,并与胃癌VEGF的促肿瘤血管新生有一定关系。
作者 周宁 陆培华 陶国清 项成
机构地区 南京医科大学附属无锡市人民医院
出处 《实用医技杂志》 2008年第33期4768-4770,共3页 Journal of Practical Medical Techniques
关键词 IL-10 IL-12 血管内皮生长因子 胃肿瘤
分类号 R735.2 [医药卫生—肿瘤]
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参考文献7

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同被引文献19

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实用医技杂志
2008年 第33期

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