2型糖尿病家系血清抵抗素的表达与胰岛素抵抗的相关性及临床意义

Expressions of serum resistin in type 2 diabetic families and its relation with insulin resistance

目的:研究2型糖尿病(T2DM)家系正常糖耐量一级亲属(一级亲属)血清抵抗素水平的变化,探讨抵抗素与胰岛素抵抗(IR)的关系。方法:收集广西壮族T2DM家系45个,在排除DM和糖耐量损害的前提下,选择一级亲属为观察组(83例),先证者的配偶或其同胞的配偶为正常对照组(76例),检测所有受试者的空腹血糖(FPG)、胰岛素(FINS)、胰岛素原(FPI)、血脂、抵抗素水平。采用稳态模型法(HOMA)计算胰岛素抵抗指数(HOMA-IR)。结果:一级亲属组的甘油三酯(TG)、FPI、FINS、HOMA-IR、抵抗素水平显著高于正常对照组,高密度脂蛋白(HDL)显著低于正常对照组。多元线性逐步回归分析显示:FPG、体质指数(BMI)、抵抗素是影响T2DM家系一级亲属IR的独立危险因素。结论:T2DM家系一级亲属在未发生糖尿病时已存在IR,抵抗素可影响T2DM家系一级亲属IR的程度。

Objective:To study the change of serum resistin level in the first-degree relatives of type 2 diabetic families and the relationship of resistin with insulin resistance.Methods:45 type 2 diabetes families in Guangxi Zhuang were recruited.The observation group comprised with 83 first-degree who was normal glucose tolerance(NGT).The normal control group comprised with 76 NGT spouses of probands or siblings.The levels of fasting blood glucose,insulin,proinsulin,lipid,and resistin were measured among two groups...