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骨桥蛋白表达与垂体腺瘤侵袭性生长的相关性研究 被引量：2

Correlation between osteopontin expression and invasive growth of pituitary adenomas
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摘要 目的探讨骨桥蛋白(Osteopontin,OPN)表达与垂体腺瘤侵袭性生长的相关性。方法分别对78例垂体腺瘤手术标本(其中侵袭性37例,非侵袭性41例)和5例来源于尸检的正常垂体组织进行检测,采用实时荧光PCR技术检测组织中OPN mRNA表达,免疫组织化学SP法检测OPN蛋白表达,结合临床资料分析OPN mRNA及其蛋白的表达与垂体腺瘤侵袭性的关系。结果侵袭性垂体腺瘤OPN mRNA表达较非侵袭性腺瘤显著增高(t=2.43,P<0.05)。OPN蛋白表达定位于细胞质,积分光密度(IOD)定量检测侵袭性腺瘤为(55.21±12.07),非侵袭性腺瘤为(48.83±13.78),两者有显著性差异(t=3.44,P<0.05)。结论OPN mRNA和蛋白在侵袭性垂体腺瘤中表达均增强,提示OPN与垂体腺瘤侵袭性生长过程有关,可能是垂体腺瘤侵袭生长的机制之一,且有望成为新的治疗靶点。 Objective To explore the correlation between osteopontin(OPN) expression and invasive growth of pituitary adenomas.Methods Samples from 78 patients with pituitary adenomas, including 37 invasive and 41 noninvasive, and 5 normal pituitary tissue specimens from autopsied patients were examined.The expressions of OPN mRNA and OPN were examined by real-time fluorescence quantitative PCR(FQ-PCR) and immunohistochemical SP method, respectively.The relation of OPN and OPN mRNA expressions to invasiveness of pituit...
作者 姜曙 唐建建 王修杰 毛伯镛
机构地区 四川大学华西医院神经外科
出处 《中国微侵袭神经外科杂志》 CAS 2008年第12期554-556,共3页 Chinese Journal of Minimally Invasive Neurosurgery
基金 四川省科技厅重大课题资助项目(编号:0040205301257)
关键词 垂体肿瘤 骨桥蛋白 肿瘤侵润 pituitary neoplasms osteopontin neoplasm invasiveness
分类号 R736.4 [医药卫生—肿瘤]
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参考文献11

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同被引文献28

  • 1石全红,霍钢,郑履平.Survivin在侵袭性垂体腺瘤中的表达及其与bcl-2、bax表达的关系[J].江西医学院学报,2005,45(4):59-62. 被引量：5
  • 2杨伟,曲元明,徐广明,韩韬.TSP1/TGFβ与垂体瘤血管生成及侵袭性的关系[J].中华神经外科杂志,2005,21(11):695-698. 被引量：6
  • 3徐伟光,朱永红,王海军,何东升,黄锦桃,冯雷.侵袭性和非侵袭性垂体腺瘤成纤维细胞的生长及凋亡比较[J].中华实验外科杂志,2006,23(5):563-565. 被引量：1
  • 4张庆原,张剑宁.VEGF、uPA在侵袭性垂体腺瘤中的表达及意义[J].中华神经外科疾病研究杂志,2007,6(2):146-149. 被引量：3
  • 5Meij BP, Lopes MB, Ellegala DB, et al. The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery. J Neurosurg, 2002,96 : 195- 208.
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  • 9Hamid T, Kakar SS. PTTG/securin activates expression of p53 and modulates its function. Mol Cancer,2004,3:18.
  • 10Takino H, Herman V, Weiss M, et al. Purine-binding factor ( nm23 ) gene expression in pituitary tumors : marker of adenoma invasiveness. J Clin Endocrinol Metab, 1995,80 : 1733-1738.

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中国微侵袭神经外科杂志
2008年 第12期

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