中药鸡血藤的镇痛实验研究

Study on Analgesic Test of Caulis Spatholobi

采用小鼠热板法、小鼠醋酸扭体法和小鼠热水缩尾法观察25%、50%和100%三种浓度的鸡血藤水煎液的镇痛作用。结果发现三种浓度的鸡血藤水煎液均可使热板所致小鼠舔足的痛阈值明显提高(P<0.05),痛阈提高率最高达112.17%;可使醋酸所致小鼠扭体潜伏期明显延长(P<0.01),扭体次数明显减少(P<0.01),抑制率最高达64.74%;可使热水所致小鼠缩尾潜伏期明显延长(P<0.01),痛阈提高率最高达81.79%。从而证实鸡血藤水煎液具有镇痛作用。

The analgesic effect of water decoction of Caulis spatholobi was observed by mice writhing test,mice tail-immersion test and hot-plate test,with three concentrations(25%,50% and 100%).It was found that given water decoction of Caulis spatholobi,mice′s pain threshold was obviously enhanced(P<0.05),the maximum of analgesic ratio was 112.17%;mice′s writhing latency was remarkably prolonged(P<0.01),writhing responses decreased markedly(P<0.01),the maximum of inhibitory ratio was 67.74%;tail-curl latenc...