氟伐他汀对血脂正常的心绞痛患者的治疗作用

Effect of fluvastatin in patients with angina and normal serum lipid level

目的:评价氟伐他汀对血脂正常的心绞痛患者的治疗作用。方法:将108例血脂正常的心绞痛患者随机分为治疗组(n=65,除常规治疗外加服氟伐他汀)和对照组(n=43,仅常规治疗),于治疗前、治疗后3、6和12个月时分别进行24h动态心电图检查,计算心肌缺血总负荷(TIB)并记录缺血相关事件。结果:在治疗的最初6个月内两组间TIB和缺血相关事件发生率差异无显著性意义;治疗12个月后治疗组TIB显著低于对照组[(63.6±4.8)mm/min对(75.2±6.4)mm/min,P<0.001],缺血相关事件也明显少于对照组(9.2%对32.6%,P<0.005)。结论:氟伐他汀对血脂正常的心绞痛患者具有一定的治疗作用,可显著改善心肌缺血,明显降低缺血相关事件的发生率。

Objective:To assess the therapeutic effect of fluvastatin in the patients with angina pectoris,however,without dyslipidemia.Methods:A cohort of 108 consecutive patients with angina pectoris but mean serum lipid was randomly assigned to fluvastatin group and control group.The former group consisting of 65 recruited patients was administered fluvastatin in addition to routine medication,whereas the latter group comprising 43 registered cases was merely offered routine remedy.Total ischemic burden(TIB)was moni...