复方中药对多囊卵巢综合征模型大鼠血清性激素、瘦素水平的影响

Influence of traditional Chinese medicine on PCOS rat model serum sex hormone T,FSH,LH,and Leptin

目的:观察多囊卵巢综合征(PCOS)模型大鼠血清性激素T、FSH、LH及瘦素(Leptin)水平的变化,探讨复方中药对PCOS模型大鼠生殖内分泌系统的影响。方法:本实验采用Poresky法进行造模,并分别以中药、西药(罗格列酮)、中西药联合用药治疗,观察治疗后大鼠体重、血清性激素及Leptin水平的变化,并进行Leptin水平与FSH、LH、LH/FSH、T、WEIGHT的相关分析。结果:复方中药能降低血清T、LH、Leptin水平及LH/FSH比值,且血清Leptin水平与LH、T呈正相关。结论:复方中药能改善PCOS模型大鼠的生殖内分泌功能,降低血清Leptin水平。

AIM:To observe the changes of serum sex hormone T,FSH,LH and Leptin,and explore the influence of traditonal Chinese medicine complex on the reproduction endocrine system in PCOS rat model.METHODS:PCOS rat model was established by Poresky method,the changes of the rats weight,serum sex hormone T,FSH,LH and Leptin were observed after the treatment with traditional Chinese medicine,western medicine(rosiglitazone),united medication,respectively,and the correlations of serum Leptin levels with FSH,LH,LH/FSH,T,We...