摘要
目的:比较醋氯芬酸缓释片和阳性对照药醋氯芬酸片治疗活动期类风湿关节炎(RA)疗效和安全性。方法:采用随机、双盲双模拟、平行对照方法,选择疾病活动期RA患者45例(试验组22例,对照组23例);试验药醋氯芬酸缓释片200 mg,每天一次;对照药醋氯芬酸片100 mg,每天2次;4周为一疗程。结果:治疗4周后,试验组总有效率为63.6%,对照组总有效率69.6%(P>0.05)。两药均能显著改善RA患者的症状和体征(P<0.05)。不良反应发生率试验组为13.0%,对照组为12.0%,两组间不良反应发生率差异无统计学意义(P>0.05)。结论:醋氯芬酸缓释片治疗RA的疗效和安全性与醋氯芬酸片类似,但用药方便。
AIM: To compare the efficacy and safety of sustained-released tablet of aceclofenac versus aceclofenac in patients with active rheumatoid arthritis(RA).METHODS: Randomized,double-blind,double-simulated,paralleled,and controlled clinical trial was performed.45 RA patients randomly assigned to two groups(treatment group n=22,controlled group n=23).The treatment group was given sustained-released tablet of aceclofenac 200 mg once a day and the controlled group was given aceclofenac 100 mg twice a day.The total...
出处
《中国临床药理学与治疗学》
CAS
CSCD
2008年第11期1282-1285,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
关节炎
类风湿
醋氯芬酸缓释片剂
治疗
arthritis
rheumatoid
sustained-released tablet of aceclofenac
treatment
