心适注射液抗动脉血栓作用机制及其对大鼠血液流变学的研究

Research of anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheology in rats

目的:研究心适注射液对大鼠血液流变学的作用及其抗动脉血栓作用机制。方法:以胶原蛋白-肾上腺素诱发小鼠体内血栓形成与冰水浴造成血瘀模型,观察体内、外血栓形成、血小板黏附率及血液流变学的改变。结果:心适注射液各剂量组均明显降低小鼠体内血栓形成以及大鼠血小板黏附率,改善急性血瘀模型大鼠血液流变学,抑制大鼠血栓形成。结论:心适注射液能改善急性血瘀模型大鼠血液流变学,有效地对抗动脉血栓的形成。

AIM:To study the anti-artery thrombosis mechanism of action and the effect of Xinshi injection on hemorheological in rats.METHODS:The thrombosis model in mice induced by collagen-adrenalin and the blood stasis model in rats induced by ice-bath were established,then the impacts of Xinshi injection on thrombogenesis in vivo and in vitro,platelet adhesion rate and hemorheology changes were observed.RESULTS:Each dose of Xinshi injection could obviously reduce the thrombosis of mice in vivo and the platelet adhe...