1[1]Blackburn EH.Stucture and function oftelomeres[J].Nature,1991,3(6319):569-573.
2[2]Feng J,Funk WD,Wang SS,et al.The RNA component of human telomerase[J].Science,1995,269(5228):1236-1241.
3[3]Bryce LA,Morrison N,Hoare SF,et al.Mapping of the gene for the human telomerase reverse transcfiptase,HTERT,to chromosome 5p15.33 by fluorescence in situ hybridization[J].Neoplasia,2000,2 (3):197-201.
5[5]Cong YS,Wright WE,Shay JW,et al.Human telomerase and its regulation[J].Microbiol Moi Biol Rev,2002,66 (3):407-425.
6[6]Artandi SE,DePinho RA,et al.Mice without telomerase:what can they teach us about human cancer?[J].Nat Med,2000,6 (8):852-855.
7[7]Pang JX,Cheng XY,Xu W,et al.Antisense Spl oligodeoxynucleotide decreases telomerase activity by inhibiting HTERT mRNA expression in Jurkat T cells[J].Acta Pharmacol Sin,2003,24 (1):91-96.
8[8]Backsch C,Wagenbach N,Nonn M,et al.Microcellmediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity[J].Genes Chromosomes Cancer,2001,31 (2):196-198.
9[9]Ancelin K,Brunori M,Bauwens S,et al.Targeting assay to study the cis functions of human telomeric proteins:evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2[J].Mol Cell Biol,2002,22 (10):3474-3487.
10[10]Zhang A,Zheng C,Lindvall C,et al.Frequent amplification of the telomerase reverse transcriptase gene in human tumors[J].Cancer Res,2000,60 (22):6230-6235.
二级参考文献18
1Shay JW, Bacchetti S. A survey of telomerase activity in human cancer [J]. Eur J Cancer, 1997, 33(5): 787-791.
2Wu A, Ichihashi M, Ueda M. Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumors [J]. Cancer, 1999,86(10):2038-2044.
3Luzar B, Poljak M, Marin IJ, et al. Quantitative measurement of telomerase catalytic subunit (hTERT) mRNA in laryngeal squamous cell carcinomas [J]. Anticancer Res, 2001, 21(6A): 4011- 4015.
4Lehner R, Enomoto T, McGregor JA, et al. Quantitative analysis of telomerase hTERT mRNA and telomerase activity in endometrioid adenocarcinoma and in normal endometrium [J]. Gynecol Oncol, 2002, 84(1):120-125.
5Hara H, Yamashita K, Shinada J, et al. Clinicopathologic significance of telomerase activity and hTERT mRNA expression in non-small cell lung cancer [J]. Lung Cancer, 2001, 34(2):219-226.
6Onoda N, Ishikawa T, Yoshikawa K, et al. Telomerase activity in thyroid tumors [J]. Oncol Rep,1998,5(6):1447-1450.
7Aogi K, Kitahara K, Buley I, et al. Telomerase activity in lesions of the thyroid: application to diagnosis of clinical samples including fine-needle aspirates [J]. Clin Cancer Res,1998, 4(8):1965-1970.
8Cheng AJ, Lin JD, Chang T, et al. Telomerase activity in benign and malignant thyroid tissues [J]. Br J Cancer, 1998,77(12):2177-2180.
9Nishida T, Nakao K, Hamaji M, et al. Overexpression of P53 protein and DNA content are important biologic prognostic factors for thyroid cancer [J]. Surgery, 1996,119(5):568-575.
10Godballe C, Asschenfeldt P, Jorgensen KE, et al. Prognostic factors in papillary and follicular thyroid carcinomas: P53 expression is a significant indicator of prognosis [J]. Laryngoscope, 1998,108(2):243-249.
2Nakamura TM,Morin GB,Chapman KB,et al.Telomerase catalytic subunit homologs from fission yeast and human.Science,1997,277(5328):955-959.
3Meyerson M,Counter CM,Eaton EN,et al.hEST2,the putative human telomerase catalytic subunit gene,is up-regulated in tumor cells and duringimmortalization.Cell,1997,90(4):785-795.
4Hahn WC,Stewart SA,Brooks MW,et al.Inhibition of telomerase limits the growth of human cancer cells.Nat Med,1999,5(10):1164-1170.
5Su CQ,Sham J,Xue HB,et al.Potent antitumoral efficacy of a novel replicative adenovirus CNHK300 targeting telomerase-positive cancer cells.JCancer Res Clin Oncol,2004,130(10):591-603.
6Zhang Q,Nie M,Sham J,et al.Effective gene-viral therapy for telomerase-positive cancers by selective replicative-competent adenovirus combiningwith endostatin gene.Cancer Res,2004,64(15):5390-5397.
8Bennett JM,Catovsky D,Daniel MT,et al.Proposals for the classification of the acute leukaemias.French-American-British (FAB) co-operativegroup.Br J Haematol,1976,33(4):451-458.
9Hartmann U,Brümmendorf TH,Balabanov S,et al.Telomere length and hTERT expression in patients with acute myeloid leukemia correlateswith chromosomal abnormalities.Haematologica,2005,90(3):307-316.
10Beillard E,Pallisgaard N,van der Velden VH,et al.Evaluation of candidate control genes for diagnosis and residual disease detection in leukemicpatients using ′real-time′quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against cancer program.Leukemia,2003,17(12):2474-2486.
