HP与PE对胆红素清除的效果对比

Analysis of the effect of Hemoperfusion (HP) and plasma exchange (PE) on the removal of bilirubin Comparative

目的探讨应用血液灌流(HP)与血浆置换(PE)治疗肝性高胆红素(TBIL≥17mol/L)血症的疗效对比观察。方法45例肝性高胆红素血症患者,在内科综合治疗同时,随机分为HP1(每天行一次HP治疗)15例,HP2(连续三次,间隔8小时)15例,与PE治疗组15三组;观察三组在治疗前、后的血清化:丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、总蛋白(TP)、球蛋白(GlO)、凝血指标:部分凝血酶原时间(APPT)、凝血酶原活动度(PTA)的变化;及三组治疗后3d总胆红素(TBIL)的反弹率。结果PE治疗组与HP1治疗组对比分析,PE组的TBIL下降程度,凝血指标的改善均优于HP1组,有统计学意义;PE治疗组与HP2治疗组对比发现TBIL的下降程度无显著性差异,但凝血指标的改善PE组优于HP2组,有统计学意义;HP2组与HP1组对比TBIL的改善有统计学意义,但凝血指标的改善无显著性差异;总胆红素(TBIL)的反弹率:PE治疗组与HP1治疗组无显著性差异,HP2组与PE组及HP1组对比有显著性差异。结论血浆置换(PE)在改善凝血机制方面有其独特的优越性,在降胆红素这方面的功能与血液灌流(...

Objective To evaluate the blood perfusion (HP) and plasma exchange (PE) in the treatment of hepatichigh bilirubin (TBIL ≥ 171 μ mol / L) Comparison of the efficacy hyperlipidemia. Methods of 45 cases of liverpatients hyperbilirubinemia, medical treatment, were randomly divided into HP1 (HP for a day trip) in 15 cases,HP2 (three consecutive interval of eight hours, n = 15), and PE treatment group 15 three groups; observed inthe three groups before and after treatment of the serum: alanine aminotransferase (A...