DPN“络损”中医辨证属性的研究

Study Diabetic Peripheral Neuropathy "Winds damges" TCM Dialectical Attribute

目的采用益气法、养血法、滋阴法、温阳法组成的中药复方,观察其对链脲佐菌素(STZ)诱导的糖尿病周围神经病变大鼠血清髓鞘碱性蛋白(MBP)、一氧化氮合酶(NOs)变化的影响,反证DPN'络损'的中医辨证属性。方法采用STZ诱导的糖尿病大鼠模型,随机分为模型组、益气组、养血组、养阴组、温阳组,另设正常对照组。益气组灌胃四君子汤;养血组灌胃四物汤;养阴组灌胃六味地黄汤;温阳组灌胃金匮肾气丸;模型组和正常对照组灌胃同容积的蒸馏水,连续8周,观察糖尿病大鼠血清MBP、NOs、血糖等指标的变化。结果模型组较正常组大鼠血清MBP含量明显增加、NOs活力明显降低(P<0.05);益气组、养阴组较模型组能明显降低MBP含量、提高Nos活力(P<0.05);养血组、温阳组较模型组,MBP含量有所降低、NOs活力有所升高,但是无统计学意义(P>0.05)。结论糖尿病周围神经病变'络损'的中医辨证属性以气阴两虚为主。

Objective Uses the profit to be mad that the law, raises the blood law, to nourish yin the law, the warm positive method composition traditional Chinese medicine compound prescription, observes it to assist the influence which to the chain urea the rhzomorph (STZ) induction around diabetes the mental illness fill- out mouse blood serum myelinic membrane alkalinity protein (MBP), the nitrogen monoxide synthase (NOs) changes counter-evidence DPN 'winds damages' the Chinese medicine dialectical attribute. Meth...