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STAT3与恶性肿瘤 被引量:1

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摘要 STAT3是信号传导与转录激活因子家族(signal transduction and activators of transcription,STATs)的重要成员。STAT3在人类多种肿瘤组织异常表达,并与肿瘤的发生、血管新生、免疫逃避等密切相关。
作者 刘洋
机构地区 长江大学医学院
出处 《长江大学学报(自科版)(下旬)》 CAS 2008年第4期90-93,共4页 Journal of Yangtze University
关键词 STAT3 肿瘤 治疗
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参考文献10

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同被引文献12

  • 1张文,王雅杰.STAT3与乳腺癌的研究进展[J].现代肿瘤医学,2007,15(3):439-441. 被引量:7
  • 2Tkach M,Rosemblit C,Rivas MA et al.p42/p44 MAPK-me-diated Stat3 Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth[J].Endocr Relat Cancer,2013,20(2):197.
  • 3Berclaz G,Altermatt HJ,Rohrbach V et al.EGFR dependent expression of STAT3(but not STAT1)in breast cancer[J].Int J Oncol,2001,19(6):1155.
  • 4Shao H,Cheng HY,Cook RG et al.Identification and charac-terization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor[J].Cancer Research,2003,63(14):3923.
  • 5Canesi L,Betti M,Lorusso LC et al.In vivo effects of Bisphe-nol A in Mytilus hemocytes:modulation of kinase-mediated signalling pathways[J].Aquat Toxicol,2005,71(1):73.
  • 6Canesi L,Lorusso LC,Ciacci C et al.Environmental estro-gens can affect the function of mussel hemocytes through rapid modulation of kinase pathways[J].Gen Comp Endocrinol,2004,38(1):58.
  • 7Hatake K,Tokudome N,Ito Y.Next generation molecular tar-geted agents for breast cancer:focus on EGFR and VEGFR pathways[J].Breast Cancer,2007,14(2):132.
  • 8Hsieh FC,Cheng G,Lin J.Evaluation of potential Stat3 reg-ulated genes in human breast cancer[J].Biochem Biophys Res Commun,2005,335(2):292.
  • 9Yu H,Jove R.The STATs of cancer new molecular targets come of age[J].Nat Rev Cancer,2004,4(2):97.
  • 10Shi ZB,Zhao D,Huang YY et al.Discovery,synthesis,and evaluation of small-molecule signal transducer and acti-vator of transcription 3 inhibitors[J].Chem Pharm Bull(Tokyo),2012;60(12):1574.

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