虚燥更平颗粒对女性更年期高血压血压变异性的影响

Influence of Xu-zao-geng-ping-granule on blood pressure variability of the patients with menopause hypertension

目的:运用虚燥更平颗粒治疗女性更年期高血压病,观察对血压变异性的影响,并观察临床疗效,从而为中医治疗女性更年期高血压证型提供临床依据。方法:将62例女性更年期高血压病阴虚内燥证患者按1∶1随机分成治疗组和对照组,分别于治疗前后进行24h动态血压监测(ABPM)、生活质量评分及临床疗效评定,分析两组患者治疗前后的血压变异和生活质量等的改善情况。结果:(1)治疗组治疗后平均收缩压、舒张压均明显下降(P<0.05),与对照组相比,治疗组24h平均收缩压、白昼平均舒张压、夜间平均收缩压、夜间平均舒张压下降更为显著(P<0.01);(2)治疗组在治疗前后其血压变异性有差异,治疗后其血压变异性明显小于治疗前(P<0.05),治疗组治疗后全天血压变异明显低于对照组。治疗组白昼收缩压变异性、白昼舒张压变异、夜间收缩压变异、夜间舒张压变异明显小于对照组,其差异性更加显著(P<0.01),而对照组治疗前后除24h舒张压变异有差异外,其他时间血压变异无明显差异性(P>0.05);(3)两组临床疗效比较,治疗组疗效优于对照组(P<0.01);(4)治疗组与对照组比较生活质量明显改善(P<0.01)。结论:虚燥更平颗粒治疗女性更年期高血压病可显著减小其血压变异性,并能改善其临床症状,提高女性更年期高血压患者的生活质量。

Objective:To study the clinical effecacy of Xu-zao-geng-ping-granule on the patients with menopause hypertension and analyzes their the blood pressure variability,treats the feminine menopause hypertension Yin-xu-nei-zao deficient for the Chinese medicine to provide the clinical basis.Methods:In accordance with the principles of 1∶1,62 cases of menopausal women with hypertensive patients were randomly divided into treatment group and control group,and ambulatory blood pressure monitoring,quality of life gra...