郁乐疏对脑卒中后抑郁模型大鼠行为学与神经功能的影响研究

The study of YuLeShu on the behavior and neurological functional of stroke rat Affiliated hospital of the Chengdu university of TCM

目的:观察郁乐疏对卒中后抑郁(PSD)大鼠神经功能恢复的影响;对PSD大鼠抑郁行为探讨其抗抑郁作用机制。方法:采用线栓法制备局灶性脑缺血大鼠模型,在此基础上综合孤养、应激处理复合制备PSD大鼠模型。运用Longa5法和水平木棒法评定卒中大鼠神经功能恢复。运用糖水实验、敞箱实验、被动躲避实验评定PSD大鼠的兴趣感变化、自发活动和探究行为等抑郁行为学改变。观察郁乐疏对卒中大鼠神经功能恢复影响,结果:中、高剂量的郁乐疏可显著改善卒中大鼠的神经功能缺陷。高剂量的郁乐疏合剂可使PSD大鼠的兴趣感下降、自发活动和探究行为降低得到显著改善。中、高剂量郁乐疏可显著改善PSD大鼠被动躲避缺陷。结论:郁乐疏对卒中大鼠的神经功能恢复有促进作用,对PSD大鼠出的抑郁行为学异常有显著的改善作用。

objective:Investigating the action of YuLeShu on the neurological functional recovery and behavior of stroke rat,To probe the anti-depressive mechanism of YuLeShu.Methods:Focal celebral ischemia rat models were made with thread embolization method.Poststroke depression rat models were established with comprehensive separately breeding and moderate unpredictable stress on this basis.The neurological functional recovery of stroke rat is assessed by longa 5 grades and horizontal bar test.Sucrose solution consu...