摘要
目的:了解事件相关电位P300与智力障碍及智商的关系。方法:对2005年1月至2007年11月在我院门诊就诊、住院收治及在我院进行智力残疾鉴定的智力障碍患者106例,进行瑞文标准推理测定和FZ位点事件相关电位P300各指标检测,并对40例正常对照也同样进行P300各指标的检测。结果:(1)与正常对照组相比,精神发育迟滞组靶刺激P3潜伏期延长(P<0.01),P2-N2峰间潜伏期延长(P<0.05～0.01),N2-P3峰间潜伏期延长(P<0.01),非靶刺激P2潜伏期延长(P<0.01),靶刺激P3波幅降低(P<0.01),P2-N2峰间波幅降低(P<0.05),N2-P3峰间波幅降低(P<0.01),非靶刺激P2波幅降低(P<0.01)。痴呆组靶刺激P3潜伏期延长(P<0.01),P2-N2峰间潜伏期延长(P<0.05～0.01),N2-P3峰间潜伏期延长(P<0.01)非靶刺激P2潜伏期延长(P<0.01),P2-N2峰间波幅降低(P<0.05),N2-P3峰间波幅降低(P<0.01),非靶刺激P2波幅降低(P<0.01),靶刺激P3波幅降低(P<0.05)。(2)精神发育迟滞组与痴呆组相比,波形分化差,P3波幅降低(P<0.05),N2-P3峰间波幅降低(P<0.05)。(3)P300潜伏期与智商水平呈负相关。结论:P300是作为判断大脑高级功能的客观指标,与智商结合测定可真实反映患者的智力障碍程度,同等智商的精神发育迟滞患者可能比痴呆患者的认知障碍更严重,这需要更多的临床研究。
Objective:To understand the relationships between the event-related potential P300 and the dysgnosia or the intelligence quotients(IQs).Methods:One hundred and six patients with dysgnosia in our hospital were reasoning tested with Raven s Standard Progress and their FZ-point event-related potential indicators of the P300 were measured between January 2005 to November 2007,and 40 cases of the normal control were also analyzed during the same term.Results:(1)Compared with those in the control group,the latenc...
出处
《华西医学》
CAS
2008年第6期1262-1263,共2页
West China Medical Journal
关键词
智力障碍
P300
智商
dysgnosia
P300
intelligence quotients（IQ）
