摘要
目的:分析器官移植术后应用他克莫司免疫抑制所致不良反应的临床特征和相关因素。方法:检索1998～2008年国内文献收载的他克莫司不良反应报道资料,进行统计、分析。结果:31例不良反应中神经系统损伤发生最多(12例,占38.7%),其次为造血系统损伤(6例,占19.3%),肝损伤(5例,占16.1%),且以神经系统损害最为严重(死亡3例);不良反应发生时间差异大,预后差。结论:不良反应发生与移植类型,治疗阶段,患者代谢能力、血药浓度等因素相关,且个体差异较大;临床应高度重视,密切观察用药后患者不良反应的发生,积极治疗。
Objective:To study the clinical characteristics and the related factors of the adverse drug reactions(ADRs)caused by Tacrolimus after organ transplantation.Methods:Relative studies retrieved in domestic medical journals between 1998 and 2008 were analyzed statistically.Results:Of the 31 ADR cases,leading the list were injury of nervous system(12 cases,38.7%),the most serious(dead 3 cases);followed in order by injury of hematopoietic system(6 cases,19.3%)and liver injury(5 cases,16.1%);The ADRs were undesira...
出处
《华西医学》
CAS
2008年第6期1298-1299,共2页
West China Medical Journal
关键词
他克莫司
不良反应
文献分析
Tacrolimus
adverse drug reaction
literature analysis
