川西地区学龄儿童抗DNA酶B在风湿热流行病学研究中的运用

Epidemiologic Study of DNase B Used in the Schoolchildren with Rheumatic Fever

目的:探讨川西地区学龄儿童抗DNA酶B抗体流行病学特点。方法:从1993年09月～1994年08月对四川省成都市青白江区城市和农村学龄儿童(年龄9～11岁),共197名(男113名,女84名)。每3个月抽血1次,用微量法统一测定血清抗DNA酶B抗体水平。结果:1.抗DNA酶B抗体滴度水平差异与季节、性别、地区关系:DNA酶B冬季稍高,其他三季相差小(P>0.05)。男性DNA酶B值高于女性DNA酶B值,其差异有统计学意义(P<0.05)。农村学生DNA酶B值冬季明显高于城市学生(P<0.05)2.DNA酶B与风湿热(RF)关系:DNA酶B随季节有一定变化,但尚未见统计学差异,以冬季稍高,而风湿热则明显秋冬季较高,两者流行趋势相似。结论:农村儿童青少年DNA酶B较城区几何滴度高,冬季较其他季节高均证实这一点。测定某一地区学龄儿童血清抗DNA酶B水平,可作为该地区RF流行水平的初步估测和进一步研究的参考。

Objective:To investigats the epidemic characteristics of Antistreptococcal DNase B in the schoolchildren of Western Sichuan region.Methods:Antistreptococcal DNase B test microtiter method was adopted to detect human sera antibody in Chengdu City s natural populations in Sichuan province.All 197 urban and rural schoolchildren(male 113,female 84)aged 9～11 years old were chose by the random cluster sampling.The schoolchildren s serum antibody against DNase B in each season from september 1993 to August 1994 wa...