雷贝拉唑对非糜烂性反流病的疗效研究

Therapeutic Efficacy of Rabeprazole in Non-erosive Reflux Disease

目的:研究雷贝拉唑对非靡烂性反流病(NERD)的治疗效果。方法:对98例NERD患者进行临床症状评分、24小时食管pH监测,随机分为两组,A组50例、予雷贝拉唑10mg、日2次、治疗4周,B组48例、予法莫替丁20mg、日2次、治疗4周,观察其对NERD临床症状的改善,24小时食管pH的变化及疗效。结果:经雷贝拉唑治疗4周后,NERD的烧心、反酸、胸痛、反食症状较法莫替丁治疗4周后有明显的改善(P<0.05),24小时食管pH监测显示,pH<4时间百分比、DeMeester评分的变化雷贝拉唑钠组较对照组有显著的差异性(P<0.05),A组治疗NERD的有效率为88%、较B组治疗的有效率62.5%有显著的差异性(P<0.05)。结论:雷贝拉唑钠可显著改善NERD的临床症状,对NERD有较佳的治疗效果,是临床治NERD首选有效的药物。

Objective:To investigate the therapeutic effect of rabeprazole in treatment of non-erosive reflux disease(NERD).Methods:98 cases of patients with NERD were carried out clinical symptoms score,24-hour esophageal pH monitoring and were randomly divided into two groups,50 cases in A group and 48 cases in B group,rabeprazole 10mg Bid and famotidine 20mg Bid were gave respectively for 4 weeks,observe the improvement of NERD clinical symptoms,the change and the therapeutic effect of 24-hour esophageal pH by them....