大鼠胶质瘤伽玛刀治疗后MRI和病理学对照研究

The control study between MRI and pathology in rat glioma after gamma knife treatment

目的大鼠胶质瘤伽玛刀照射后,比较MRI增强扫描和病理学的对应关系。方法建立大鼠C6脑胶质瘤模型,行伽玛刀照射后,于不同时间点(2d、7d、14d、21d)观察肿瘤MRI、光镜变化,并与对照组(不接受伽玛刀照射)进行比较。结果伽玛刀照射后,MRI增强扫描显示肿瘤体积缩小,强化程度减轻,中心坏死,瘤周水肿信号范围扩大;光镜下见亦可见到肿瘤中心坏死,瘤周水肿;并且瘤内出现炎性细胞浸润,且水肿区内部分肿瘤细胞浸润。结论脑胶质瘤伽玛刀照射后,MRI增强扫描与病理学在观察肿瘤坏死和水肿方面基本一致;但MRI难以显示肿瘤细胞的活性以及浸润的散在瘤细胞。

Objective To compare the correlation between MRI and pathology after gamma knife treatment of rat glioma.Methods C6 glioma model with rats were established and the rats in treatment group accepted gamma knife treatment,at different time(2d,7d,14d,21d),MRI and histology study was performed and compared with the control rats(without gamma knife irradiation).[WT5" HZ]Results [WT5" BZ] On the enhanced MRI,the tumor were shrinked in size,necerosis occurred in the tumor center,and edma signal spread around tumor....