摘要
目的:探讨灵芝多糖对失血性休克再灌注过程中肠黏膜损伤的保护作用。方法:复制家兔失血性休克再灌注复苏模型,随机行假手术(S组)、生理盐水再灌注复苏(NS组)和质量分数为1%的GLP再灌注复苏(LS组),于放血前(BI)、休克40 min(S40)、再灌注复苏40 min(R40)和90 min(R90)时,观察各组细菌的移位情况及检测肠黏膜SOD活性、血浆和肠黏膜MDA和NO含量;同时取回肠末端观察肠黏膜的损伤情况。结果:(1)随着再灌注复苏时间的延续,NS组血液细菌阳性率增加,细菌移位增加,明显高于LS组和S组,同时肠黏膜的损伤也明显重于LS组和S组(P<0.05);(2)NS组和LS组肠黏膜SOD活性明显低于S组,而LS组又明显高于NS组;NS组和LS组休克40 min时血浆和肠黏膜MDA和NO含量明显高于S组,而LS组又明显低于NS组(P<0.05)。结论:GLP对SH-R肠黏膜损伤有保护作用,这可能与其增强SOD活性、减少NO的生成,抑制脂质过氧化反应有关。
Objective:To study the protective effect of GLP on intestinal mucosa injury in hemorrhagic shock reperfusion rabbit.Methods:With the model of HS-Rin rabbits,the animals were divided into three groups:sham operation group(S group),reperfusion with N-S group(NS group),reperfusion with 1% GLP group(LS group).The incidence rates of bacterial translocation were observed at the time of pre-shock,shock 40 min,post-reperfusion 40 min and 90 min respectively.The content of NO and MDA in serum and intestinal mucosa,t...
出处
《中国误诊学杂志》
CAS
2009年第3期514-516,共3页
Chinese Journal of Misdiagnostics
基金
河南省教育厅自然科学研究项目(编号:2006310021)
关键词
肠粘膜/损伤
再灌注损伤/中药疗法
灵芝/药理学
兔
动物
Intestinal Mucosa/injuries
Reperfusion Injury/ZHONG YAO LIAO FA
GANODERMA LUCIDUM/pharmacology
Rabbits
Animals
