艾迪注射液对胃癌患者术后细胞免疫功能的影响

Effect of Aidi Injection on Cellular Immunity in Postoperative Patients with Gastric Cancer

目的探讨艾迪注射液对胃癌患者术后细胞免疫功能的影响。方法将40例行胃癌根治术的患者随机分为A、B两组,各20例,另选择40例健康体检者为对照组。B组患者仅给予常规抗炎支持治疗,A组患者术后在常规治疗基础上给予艾迪注射液静脉滴注。比较胃癌组和对照组术前细胞免疫功能〔用外周血T细胞亚群(CD3+、CD4+、CD8+T细胞及CD4+/CD8+)变化判断细胞免疫功能〕及A、B组患者术前与术后14d的细胞免疫功能。结果(1)胃癌患者术前CD3+、CD4+、CD8+T细胞所占百分比及CD4+/CD8+值与对照组比较,差异均有统计学意义(P<0.01)。(2)B组患者术后CD3+、CD4+、CD8+T细胞所占百分比及CD4+/CD8+值与术前比较,差异均无统计学意义(P>0.05)。(3)A、B两组患者术后CD3+、CD4+、CD8+T细胞所占百分比及CD4+/CD8+值间差异有统计学意义(P<0.01)。结论胃癌患者细胞免疫功能处于抑制状态,手术不能逆转胃癌患者的免疫抑制状态,而术后应用艾迪注射液可逆转胃癌患者的免疫抑制状态。

Objective To investigate the effect of Aidi injection on cellular immune function in postoperative patients with gastric cancer.Methods Totally 40 gastric cancer patients receiving radical operation were randomly divided as A and B groups,with 20 in each;and 40 healthy physical examinees were enrolled as the controls.After operation,the patients in B group received only conventional anti-inflammatory treatment,and those in A group received additional Aidi injection.The immune functions(Changes of CD3+,CD4+,...