胆管内用药预防内镜下胰胆管逆行造影所致急性胰腺炎

Injection of medicines in the bile duct to prevent the acute pancreatitis in the ERCP

目的探讨胆管内用药对预防内镜下胰胆管逆行造影(ERCP)后出现高淀粉酶血症及急性胰腺炎的效果。方法在1 100例ERCP患者操作中,通过胆管内直接注入氢溴酸山莨菪碱、硫酸庆大霉素,观察操作后3小时、16小时血淀粉酶的升高程度,随机对比452例非胆管内用药患者,并采用医学统计方法,分析用药组与非用药组患者血淀粉酶变化的显著性意义(χ2检验)。结果治疗组血淀粉酶的升高频次及程度,明显低于对照组(术后3小时血淀粉酶升高在治疗组中有325例,占29.5%,对照组有288例,占63.7%,χ2值为156.63;术后16小时血淀粉酶升高在治疗组中有218例,占19.8%,对照组有263例,占58.2%,χ2值为1 409.52)。结论ERCP患者在操作中胆管内注入氢溴酸山莨菪碱、硫酸庆大霉素,能够明显降低ERCP后患者的高淀粉酶血症及急性胰腺炎的发病率。

Objective To explore the effectiveness of injecting medicines to the bile duct in the prevention of the hyperamylasemia and the acute pancreatitis after the endoscopic retrograde cholangio pancreatography(ERCP).Methods In 1 100 cases of the patients subjected to ERCP,after injecting the anisodamine and gentamycin to the bile duct for 3 hours and 16 hours,the level of the amylase in blood were checked.The data were compared with that from 452 patients without using medicine in the bile duct.The alteration of...