摘要
目的:探究电针治疗抑郁症的作用机制。方法:将健康Wistar大鼠随机分为正常组10只,模型组和电针组各11只,慢性应激法21 d造模。电针组选穴"百会""三阴交",以频率2 Hz、电流强度1 mA,行电针治疗20 min,每日1次。14 d后处死动物,通过免疫组化法测定5-羟色胺(5-HT)和乙酰胆碱酯酶(AChE)在海马区的积分吸光度(IOD)值。结果:造模后造模组与正常组比较,水平、垂直运动次数和糖水消耗量均减少(P<0.001)。模型组与正常组相比,5-HT和AChE的IOD值减小(P<0.05);电针组与模型组相比,两指标的IOD值明显升高(P<0.05)。结论:抑郁大鼠海马5-HT和AChE活性降低,电针可明显提高大鼠海马中5-HT、AChE的表达,从而发挥其抗抑郁作用。
Objective To investigate the influence of electroacupuncture(EA) on 5-serotonin(5-HT) and acetyl cholinesterase(AChE) activities in hippocampus tissue in chronic stressed-induced depression rats.Methods Thirty-two Wistar rats were randomized into normal control group(n=10),model group(n=11) and EA group(n=11).Chronic depression model was established by lonely raising,and chronic unpredictable mild stress for 21 days.EA(2 Hz,1 mA) was applied to "Baihui"(GV 20) and "Sanyinjiao"(SP 6) for 20 minutes,once dail...
出处
《针刺研究》
CAS
CSCD
北大核心
2009年第1期16-20,共5页
Acupuncture Research
