脑梗死和脑出血患者急性期血清可溶性TRAIL的表达

Expression of serum soluble TRAIL in patients with acute cerebral in farction and cerebral hemorrhage

目的探讨脑梗死和脑出血患者急性期血清可溶性肿瘤坏死因子(TNF)相关凋亡诱导配体(sTRAIL)表达水平的变化。方法选择脑梗死、脑出血急性期患者分别为45、20例,健康老年人20例,分别用酶联免疫吸附法测定血清sTRAIL水平。结果脑梗死急性早、后期血清sTRAIL分别为(115.94±35.25)(、101.90±16.14)pg/mL,均显著高于正常对照组,脑出血组和正常对照组之间差异无统计学意义,脑梗死时患者血清sTRAIL浓度与梗死面积有关。结论sTRAIL诱导的细胞凋亡是脑梗死后神经元损伤的因素之一。

Objective To explore the changes of sTRAIL in patients with acute phase of cerebral infarction and cerebral hemorrhage.Methods 45 cases of acute cerebral infarction and 20 cases of acute cerebral hemorrhage were enrolled in this study,and 20 healthy people served as the control group.The concentration of serum sTRAIL was determined by enzyme-linked immuno sorbent assay.Results The concentrations of sTRAIL were(115.94±35.25)and(101.90±16.14)pg/mL in patients with early and late acute phase of cerebral infarc...