摘要
目的:研究醋柳黄酮自微乳制剂的制备工艺和溶出度测定方法。方法:考察了醋柳黄酮在不同油、乳化剂、助乳化剂中的平衡溶解度,通过绘制伪三元相图、自乳化速率、粒径及稳定性的考察,确定最佳处方;并绘制了醋柳黄酮自乳化片剂2h溶出曲线。结果:自微乳制剂最佳处方的比例为中链甘油三酸酯-Cremophor EL-1,2-丙二醇(0.5︰5.7︰3.8),微乳平均粒径为12.1nm,10min溶出度较心达康片提高131%。结论:醋柳黄酮自微乳粒径小,稳定性好,溶出度较市售制剂得到明显改善。
Objective:To develop self-microemulsifying preparations of total flavones of Hippophae Rhamnoides L.(TFH) and the determination method of dissolution. Method:The equilibrium solubility of TFH in different compositions of oils,emulsifier and assistant emulsifier was investigated. The self-microemulsion formula was optimized by constructing the pseudo-ternary phase diagrams of blank SMEDDS determining the self-microemulsifying efficiency and the stability of the SMEDDS. The 2 hours dissolution curve of TFH se...
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第1期43-46,共4页
China Journal of Chinese Materia Medica
基金
上海高校选拔培养优秀青年教师科研专项基金(szy-07034)
上海中医药大学“大学生创新活动计划”资助项目(SHUTCMCXHDZ18)
关键词
醋柳黄酮
自微乳
伪三元相图
溶出度
total flavones of Hippophae rhamnoides
self-microemusifying
pseudo-ternary phase diagrams
dissolution rate
