功能基因组学方法在药用植物次生代谢物研究中的应用

Functional genomic approaches to explore secondary metabolites in medicinal plants

目的:药用植物遗传背景基础资料缺乏,对其次生代谢途径及其调控机制的认识不够深入,阻碍了细胞或组织培养、代谢工程等在获取高价值次生代谢物上的广泛应用。功能基因组学方法,尤其是cDNA-AFLP转录轮廓分析和代谢组学的整合运用,将次生代谢物的变化与相关基因的表达相关联,在挖掘次生代谢物生物合成相关基因、探索次生代谢途径方面展现出广阔的应用前景,是植物次生代谢物研究的新趋势和重要手段之一,将有力地促进药用植物资源更好的开发利用。

Extensive genomic data concerning medicinal plants are rather scarce and insights of the secondary metabolic pathways and their regulatory mechanism are insufficient,hampering the broad application of cell or tissue cultivation and metabolic engineering to producing high-value secondary metabolites. The integration of cDNA-AFLP based transcript profiling and metabolomics,a new development of functional genomic approaches could establish correlations between the changes of secondary metabolites and expressio...