戊乙奎醚-异丙酚-芬太尼静脉麻醉在结肠镜下肠息肉高频电切除术中的应用

The Application Of Penehyclidine Hydrochloride-Propofol-Fentanyl Intravenous Anesthesia In The Colon Polyps Resection Surgery With Colonoscopy

目的:观察戊乙奎醚-异丙酚-芬太尼静脉麻醉在结肠镜下肠息肉高频电切除手术中的麻醉效果。方法:预行结肠镜下肠息肉高频电切除术的患者68例,随机分为A组(异丙酚+芬太尼)和B组(戊乙奎醚+异丙酚+芬太尼),各34例。A组予以丙泊酚1～2mg/kg及芬太尼1～2μg/kg静脉注射;B组予以戊乙奎醚0.02mg/kg、丙泊酚1～2mg/kg及芬太尼1～2μg/kg静脉注射。两组术中均持续静脉泵注丙泊酚20～25ml/h及芬太尼2μg/h。直到患者进入浅睡眠状态,睫毛反射消失后,开始进行肠镜检查或治疗。结果:镇痛效果、BP、HR、SpO2、手术时间、苏醒时间、离院时间及术中呼吸抑制和术后头晕等不良反应两组无统计学差异。B组芬太尼的用药总量显著低于A组(P<0.05),A组术中口腔分泌物增多的发病率和术后恶心呕吐的发病率明显高于B组(P<0.01)。结论:戊乙奎醚-异丙酚-芬太尼静脉麻醉技术,由于其起效快、镇痛完善、苏醒迅速、不良反应较少等特点,可较安全有效地应用于结肠镜下肠息肉高频电切除手术中。

Objective:To Observe effect of penehyclidine hydrochloride-propofol-fentanyl intravenous anesthesia in colon polyps high-frequency electrical resection surgery with colonoscopy.Methods:68 cases of patients with Pre-trip intestinal polyps high-frequency electrical excision with the colonoscopy were divided into Group A (propofol + fentanyl) and group B (penehyclidine hydrochloride + propofol + fentanyl), 34 cases respectively.Group A was injected with propofol 1~2 mg/kg and fentanyl 1~2 μg/kg intravenously; ...