苦参水提物对低氧模型小鼠的保护作用

Protective effects of aqueous extract from Sophora flavescens Ait. on hypoxic ice

目的观察苦参水提物对低氧模型小鼠的保护作用。方法分别采用腹腔注射异丙肾上腺素、亚硝酸钠、小鼠断头和失血性休克等方法制备低氧模型,观察苦参水提物对低氧小鼠耗氧量、存活时间、心脏搏动时间和张口呼吸时间的影响。结果灌胃苦参水提物10和20 g.kg-1能明显延长异丙肾上腺素致心肌耗氧增加小鼠的耐缺氧存活时间,降低耗氧量;能明显延长亚硝酸钠中毒小鼠的存活时间、断头鼠头的张口呼吸时间和失血性休克小鼠的心脏搏动时间。结论苦参水提物对缺氧心肌、缺氧脑组织及组织缺氧模型均有保护作用。

Objective: To study the protective effects of aqueous extract from Sophora flavescens Ait.against hypoxic mice.Methods: The hypoxic animal models were made by means of injecting isoprenaline or sodium nitrite or decapitation.The effects of aqueous extract from Sophora flavescens Ait.were observed by measuring the oxygen consumption,survival tim,cardiac beating time and gasping time in hypoxic mice.Results: When mice were intragastrically administered with aqueous extract of Sophora flavescens Ait.at the dos...