病毒性肝炎患者血清白细胞介素-18水平变化及其临床意义

Serum Level of Interleukin-18 in Patients with Viral Hepatitis and Its Clinical Significance

目的:探讨血清白细胞介素-18水平与病毒性肝炎的关系。方法:用ELISA检测正常对照组、中度慢性乙型肝炎、肝硬化、重症肝炎及乙戊肝重叠感染患者组血清IL-18水平。结果:病毒性肝炎患者血清IL-18水平均高于正常对照组,血清白蛋白水平与血清IL-18水平呈负相关(r=-0.315,P<0.01);血清总胆红素水平与血清IL-18水平呈正相关(r=0.677,P<0.01);血清ALT与血清IL-18水平呈正相关(r=0.898,P<0.01)。结论:IL-18在病毒性肝炎发病中具有重要作用,并在一定程度上与肝损害程度相关。

Objective:To explore the relationship between serum interleukin-18 and pathogenesis in patients with viral hepatitis. Methods: The serum level of interleukin-18 was detected by ELISA respectively in 80 patients with viral hepatitis and 20 controls. The 80 patients were divided into four groups as moderate chronic hepatitis、 liver cirrhosis、 chronic severe hepatitis and hepatitis virus B and hepatitis viral E confection. Result: Comparing with controls, the serum level of interleukin-18 in patients with vira...